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조직의 변성 / 재생 및 암의 연구에서 설치류 유도 성 텔로 머라 대립 유전자를 활용
JoVE Journal
医学
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JoVE Journal 医学
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

조직의 변성 / 재생 및 암의 연구에서 설치류 유도 성 텔로 머라 대립 유전자를 활용

DOI:

08:34 min

April 13, 2015

, , , , , ,

  • 00:05標題
  • 01:35Reactivation of Telomerase in mTERT-ER and LSL-mTERT Mice In Vivo
  • 02:33Isolation of Neural Stem Cells and Reactivation of Telomerase In Vitro
  • 05:07Telomere FISH
  • 06:37Results: Effect of Telomerase Reactivation
  • 08:01Conclusion

概要

自動翻訳

Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.

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