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Die Mesenteriallymphknoten Duct Cannulated Rattenmodell: Anwendung auf die Bewertung der Darm Lymphatische Drug Transport
JoVE Journal
免疫学と感染
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JoVE Journal 免疫学と感染
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Die Mesenteriallymphknoten Duct Cannulated Rattenmodell: Anwendung auf die Bewertung der Darm Lymphatische Drug Transport

DOI:

13:17 min

March 06, 2015

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  • 00:05標題
  • 02:10Cannulation of the Mesenteric Lymph Duct
  • 05:56Cannulation of the Duodenum and Carotid Artery
  • 10:14Results: Representative Mesenteric Lymph Flow Rate and Lipid and Drug Transport Data
  • 12:22Conclusion

概要

自動翻訳

Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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