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A linfa mesentérica Duct canulada Rat Modelo: Aplicação para a Avaliação de Intestinal Linfática transporte da droga
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JoVE Journal 免疫学と感染
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

A linfa mesentérica Duct canulada Rat Modelo: Aplicação para a Avaliação de Intestinal Linfática transporte da droga

27,961 Views

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13:17 min

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March 06, 2015

DOI:

10.3791/52389-v

DOI:
10.3791/52389-v

•

13:17 min
March 06, 2015

•

38 Views
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1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences,Monash University (Parkville Campus)

概要

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Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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Mesenteric Lymph DuctIntestinal Lymphatic SystemLymph FlowLymph CompositionLymphatic Drug TransportLymph CannulationRat Model

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Trevaskis, N. L., Hu, L., Caliph, S. M., Han, S., Porter, C. J. The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport. J. Vis. Exp. (97), e52389, doi:10.3791/52389 (2015).

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