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An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
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February 05, 2015
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To address mechanisms of demyelination and neuronal apoptosis in cortical lesions of inflammatory demyelinating disorders, different animal models are used. We here describe an ex vivo approach by using oligodendrocyte-specific CD8+ T-cells on brain slices, resulting in oligodendroglial and neuronal death. Potential applications and limitations of the model are discussed.
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Göbel, K., Bittner, S., Cerina, M., Herrmann, A. M., Wiendl, H., Meuth, S. G. An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices. J. Vis. Exp. (96), e52205, doi:10.3791/52205 (2015).
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