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Immunology and Infection

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JoVE Journal Immunology and Infection
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
 

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Article DOI: 10.3791/52205-v • 06:36 min • February 5th, 2015
February 5th, 2015 •
1, 1,2, 3, 1, 1, 1,3
1Department of Neurology, University of Münster, 2Germany and Interdisciplinary Center for Clinical Research (IZKF) Münster, 3Institute of Physiology I - Neuropathophysiology I, University of Münster

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To address mechanisms of demyelination and neuronal apoptosis in cortical lesions of inflammatory demyelinating disorders, different animal models are used. We here describe an ex vivo approach by using oligodendrocyte-specific CD8+ T-cells on brain slices, resulting in oligodendroglial and neuronal death. Potential applications and limitations of the model are discussed.

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Ex Vivo Model Oligodendrocyte-directed T-cell Attack Acute Brain Slices Histopathological Findings Grey Matter Lesions Inflammatory Demyelinating Disorders Multiple Sclerosis CD8+ T-cells Myelin- And Oligodendrocyte-related Antigens Neuronal Apoptosis Animal Models Pathophysiological Processes Collateral Neuronal Cell Death Mechanisms And Time Response In Vitro Activated Oligodendrocyte-specific CD8+ T-cells Myelin And Neuronal Damage Analysis
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