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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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JoVE Journal 免疫学と感染
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

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05:53 min

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July 06, 2013

DOI:

10.3791/50409-v

DOI:
10.3791/50409-v

•

05:53 min
July 06, 2013

•

1 Views
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1ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Centre de Recherche d’Immunologie et d’Hématologie,Université de Strasbourg

概要

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Human Cytomegalovirus (HCMV) infection of neonates represents an important cause of mental retardation, yet the molecular events leading to virus-induced pathogenesis are still poorly understood. To investigate the dynamics of brain infection, we adapted whole-animal in vivo imaging to perform time-course analysis of neonates infected with a luciferase-recombinant virus.

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In Vivo ImagingMouse CytomegalovirusMCMVNeonatal InfectionCentral Nervous SystemCNSViral DisseminationLuciferase ReporterTime-course Analysis

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Cite this Article

Ostermann, E., Macquin, C., Bahram, S., Georgel, P. Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates. J. Vis. Exp. (77), e50409, doi:10.3791/50409 (2013).

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