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Methods for Intravenous Self Administration in a Mouse Model
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December 08, 2012
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The intravenous self-administration (IVSA) paradigm is considered to be the gold standard in examining the reinforcing properties of drugs of abuse in rodents. This manuscript outlines the experimental procedures and surgical techniques necessary to obtain reliable IVSA data. In particular, meticulous catheter implantation and maintenance are highlighted.
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Kmiotek, E. K., Baimel, C., Gill, K. J. Methods for Intravenous Self Administration in a Mouse Model. J. Vis. Exp. (70), e3739, doi:10.3791/3739 (2012).
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