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Methods for Intravenous Self Administration in a Mouse Model
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December 08, 2012
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The intravenous self-administration (IVSA) paradigm is considered to be the gold standard in examining the reinforcing properties of drugs of abuse in rodents. This manuscript outlines the experimental procedures and surgical techniques necessary to obtain reliable IVSA data. In particular, meticulous catheter implantation and maintenance are highlighted.
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Intravenous Self-administrationIVSA ParadigmDrug ReinforcementDrugs Of AbuseCocaineSchedule Of ReinforcementMeasurement Of Drug ConsumptionTiming And Pattern Of IV InjectionsIntravenous Route Of AdministrationConfounds Related To First Pass Metabolism Or TasteBlood And Brain Drug LevelsCatheter Placement During SurgeryDaily Catheter Flushing And MaintenanceAnimal Housing And Acclimation MethodsOperant TrainingCatheter Implantation Surgery
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Kmiotek, E. K., Baimel, C., Gill, K. J. Methods for Intravenous Self Administration in a Mouse Model. J. Vis. Exp. (70), e3739, doi:10.3791/3739 (2012).
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