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Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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October 28, 2011
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We have established a protocol for induction of neuroblasts direct from pluripotent human embryonic stem cells maintained under defined conditions with small molecules, which enables derivation of a large supply of human neuronal progenitors and neuronal cell types in the developing CNS for neural repair.
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Human Neuronal ProgenitorsNeuronsPluripotent Human Embryonic Stem CellsSmall Molecule InductionCell-based TherapiesCentral Nervous System (CNS)Neural Stem CellsExpansion AbilityPlasticityTrophic And Neuroprotective MoleculesPluripotent HESCsNeurological DisordersDifferentiation PotentialDevelopmental StudyClinical TranslationMulti-lineage InclinationGerm Layer
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Parsons, X. H., Teng, Y. D., Parsons, J. F., Snyder, E. Y., Smotrich, D. B., Moore, D. A. Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction. J. Vis. Exp. (56), e3273, doi:10.3791/3273 (2011).
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