This content is Free Access.
GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
24,903 Views
•
09:59 min
•
July 17, 2011
DOI:
概要
Automatically generated
We use the patch-clamp technique to measure GABA-activated single-channel currents (GABAA channels, GABAA receptors) and the synaptic and tonic currents they generate in neurons. Activation of the channels decreases neuronal excitability in health and disease 1,2,3,4.
Explore More Videos
GABA-activatedSingle-channelTonic CurrentsRat Brain SlicesGABAA ChannelsSynapsesPhasic CurrentsChloride ChannelPentameric GABA-gated ChannelChannel SubunitsFamiliesAlphasBetasFunctional ChannelSub-type SpecificNeuronal InhibitionPharmacological AgentsPatch-clamp TechniqueFunctional PropertiesHippocampal Brain SlicesSingle-channel CurrentsWhole-cell CurrentsGABA ConcentrationsDrugsIntra And Extracellular Factors
Read Article
Cite this Article
Jin, Z., Jin, Y., Birnir, B. GABA-activated Single-channel and Tonic Currents in Rat Brain Slices. J. Vis. Exp. (53), e2858, doi:10.3791/2858 (2011).
Copy