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TDP-43在斑马鱼幼虫脊髓运动神经元中的光遗传学相变

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

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TDP-43在斑马鱼幼虫脊髓运动神经元中的光遗传学相变

5,742 Views

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07:14 min

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February 25, 2022

DOI:

10.3791/62932-v

DOI:

10.3791/62932-v

•

07:14 min

February 25, 2022

•

3 Views

Kazuhide Asakawa¹, Hiroshi Handa¹, Koichi Kawakami^2,3

¹Department of Chemical Biology,Tokyo Medical University, ²Division of Molecular and Developmental Biology,National Institute of Genetics, ³Department of Genetics,Graduate University for Advanced Studies (SOKENDAI)

Summary

我们描述了一种以斑马鱼为模型的模式，通过光在脊髓运动神经元中诱导TAR DNA结合蛋白43（TDP-43）的相变。

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