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חקירת התפקיד הטרנססאני של משתיק הRUNX1 נית על ידי CRISPR/Cas9 Ribonucleoprotein בתאי לוקמיה מיאלואיד חריפה

JoVE Journal
Genetica

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JoVE Journal Genetica

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

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חקירת התפקיד הטרנססאני של משתיק הRUNX1 נית על ידי CRISPR/Cas9 Ribonucleoprotein בתאי לוקמיה מיאלואיד חריפה

7,006 Views

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09:16 min

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September 01, 2019

DOI:

10.3791/60130-v

DOI:

10.3791/60130-v

•

09:16 min

September 01, 2019

•

11 Views

Chi-Keung Cheng, Terry H.Y. Wong, Yuk-Lin Yung, Nelson C.N. Chan, Margaret H.L. Ng²

¹Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital,The Chinese University of Hong Kong, ²State Key Laboratory in Oncology in South China,The Chinese University of Hong Kong

Tags

Keyword Extraction:RUNX1 Intronic Silencer CRISPR/Cas9 Ribonucleoprotein Acute Myeloid Leukemia Cis-regulatory Elements Gene Expression Transcriptional Role Hematopoietic Cells Electroporation Cas9 Nuclease GRNA RNP Complex Fragment Analysis

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