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腫瘍抗原特異的T細胞の生成にヒト誘導多能性幹細胞を用いた

JoVE Journal
Ricerca sul cancro

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JoVE Journal Ricerca sul cancro

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

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腫瘍抗原特異的T細胞の生成にヒト誘導多能性幹細胞を用いた

9,860 Views

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10:57 min

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October 24, 2019

DOI:

10.3791/59997-v

DOI:

10.3791/59997-v

•

10:57 min

October 24, 2019

•

5 Views

Meghan L. Good*^1,2, Raul Vizcardo*^1,2, Takuya Maeda^1,2, Naritaka Tamaoki^1,2, Parisa Malekzadeh¹, Hiroshi Kawamoto³, Nicholas P. Restifo^1,2

¹Surgery Branch,National Cancer Institute, NIH, ²Center for Cell-Based Therapy,National Cancer Institute, NIH, ³Laboratory of Immunology, Institute for Frontier Life and Medical Sciences,Kyoto University

Summary

本稿では、OP9/DLL1共培養系を用いて機能性腫瘍抗原特異的人工多能性幹細胞由来CD8αβ+単陽性T細胞を生成する方法について説明する。

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