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Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
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Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
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July 18, 2019
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Convection-enhanced delivery (CED) is a method enabling effective delivery of therapeutics into the brain by direct perfusion of large tissue volumes. The procedure requires the use of catheters and an optimized injection procedure. This protocol describes a methodology for CED of an antibody into a mouse brain.
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Beffinger, M., Schellhammer, L., Pantelyushin, S., vom Berg, J. Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery. J. Vis. Exp. (149), e59675, doi:10.3791/59675 (2019).
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