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建立与艾滋病毒相关的肝脏发病机制的双人性化TK-NOG小鼠模型
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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建立与艾滋病毒相关的肝脏发病机制的双人性化TK-NOG小鼠模型

8,340 Views

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00:10 min

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September 11, 2019

DOI:

10.3791/58645-v

DOI:
10.3791/58645-v

•

00:10 min
September 11, 2019

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4 Views
, , , ,
1Department of Pharmacology and Experimental Neuroscience,University of Nebraska Medical Center, 2Department of Pathology and Microbiology,University of Nebraska Medical Center

Summary

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该协议提供了一种可靠的方法，建立人类免疫系统和肝细胞的人性化小鼠。通过注射人肝细胞和CD34实现的双重组免疫缺陷小鼠–造血干细胞易受人体免疫缺陷病毒-1感染和重述肝损伤的影响，如艾滋病毒感染者。

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Cite this Article

Dagur, R. S., Wang, W., Makarov, E., Sun, Y., Poluektova, L. Y. Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis. J. Vis. Exp. (151), e58645, doi:10.3791/58645 (2019).

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