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Immunologia e infezioni

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立体定向移植人胶质瘤多形性移植小鼠细胞毒性免疫细胞模型的研究

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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

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立体定向移植人胶质瘤多形性移植小鼠细胞毒性免疫细胞模型的研究

DOI:

10.3791/57870-v

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11:15 min

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September 01, 2018

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Ulrich Jarry*^1,2, Noémie Joalland*^1,2, Cynthia Chauvin*^1,2, Béatrice Clemenceau^2,3, Claire Pecqueur², Emmanuel Scotet²

¹INSERM, CNRS, Université d’Angers, Université de Nantes,CRCINA, ²Immunotherapy, Graft, Oncology,LabEx IGO, ³Hopital de Nantes,Hotel Dieu

Capitoli

00:01Titolo
01:37Preoperative Effector Cells Preparation
03:50Stereotactic Injection: Surgical Procedure
07:33Representative Results
09:50Conclusion

Summary

Traduzione automatica

在这里, 我们提出了一项协议, 以制备和立体定向管理的异基因人淋巴细胞在 immunodeficient 小鼠携带原位人原发性脑肿瘤。本研究为 intrabrain 细胞免疫疗法的可行性和抗肿瘤疗效提供了概念验证。

Tags

Keywords: Glioblastoma Multiforme Cellular Immunotherapy Cytotoxic Immune Cells Orthotopic Xenografts Stereotactic Injection GBM-reactive Effector Cells NSG Mouse Model Tumor Microenvironment Adoptive Cell Transfer

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