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Immunology and Infection
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JoVE Journal Immunology and Infection
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
 

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Article DOI: 10.3791/57870-v • 11:16 min • September 1st, 2018
September 1st, 2018 •
*1,2, *1,2, *1,2, 1,2,3, 1,2, 1,2
1INSERM, CNRS, Université d'Angers, Université de Nantes, CRCINA, 2Immunotherapy, Graft, Oncology, LabEx IGO, 3Hopital de Nantes, Hotel Dieu
* These authors contributed equally

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Here, we present a protocol for the preparation and the stereotaxic administration of allogeneic human lymphocytes in immunodeficient mice carrying orthotopic human primary brain tumors. This study provides a proof-of-concept for both the feasibility and the antitumor efficacy of intrabrain-delivered cellular immunotherapies.

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Stereotactic Adoptive Transfer Cytotoxic Immune Cells Murine Models Orthotopic Human Glioblastoma Multiforme Xenografts GBM Primary Brain Tumor Aggressive Treatments Surgery Radiotherapy Chemotherapy Poor Prognosis Cellular Immunotherapies Highly-invasive GBM Cells Tumor Relapse GBM-reactive Cytotoxic Immuno Factors Concentrated Cellular Immunotherapy Residual Malignancy Immunodeficient NSG Mice Orthotopic Primary Human GBM Xenografts Intratumoral Injections Isolation And Amplification Of Immune Effector Cells Intercranial Injection Stereotactic Injection Mouse Brain
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