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戊四氮诱导点燃小鼠模型
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Neuroscienze
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JoVE Journal Neuroscienze
Pentylenetetrazole-Induced Kindling Mouse Model
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戊四氮诱导点燃小鼠模型

DOI:
10.3791/56573-v

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07:06 min

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June 12, 2018

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,
1Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Capitoli

  • 00:04Titolo
  • 00:38Injection of PTZ
  • 01:20Three Chamber Test
  • 04:18Contextual Fear Discrimination
  • 05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
  • 06:26Conclusion

Summary

Traduzione automatica

Traduzione automatica

本协议描述了一种戊四氮化学点燃方法, 并提供了一种小鼠癫痫模型。该协议还可用于调查小鼠癫痫发作后癫痫诱导和发病机制的脆弱性。

Tags

Pentylenetetrazole-Induced KindlingMouse ModelEpilepsySeizureHistological ChangesNeuropsychiatric DisordersPTZSodium ChlorideIntraperitoneal Injection129 SV MiceThree-Chamber ApparatusHabituationSocial InteractionBehavioral Parameters

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