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Espectroscopia óptica difusa para la evaluación cuantitativa de la radiación ionizante aguda La toxicidad cutánea inducida utilizando un modelo de ratón
JoVE Journal
Medicina
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JoVE Journal Medicina
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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Espectroscopia óptica difusa para la evaluación cuantitativa de la radiación ionizante aguda La toxicidad cutánea inducida utilizando un modelo de ratón

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06:21 min

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May 27, 2016

DOI:

10.3791/53573-v

DOI:
10.3791/53573-v

•

06:21 min
May 27, 2016

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3 Views
, , , , , ,
1Department of Radiation Oncology,University of Toronto, 2Department of Physics,Ryerson University, 3Department of Medical Biophysics,University of Toronto, 4Ontario Cancer Institute / Campbell Family Institute for Cancer Research

Summary

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We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.

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Cite this Article

Chin, L., Korpela, E., Kim, A., Yohan, D., Niu, C., Wilson, B. C., Liu, S. K. Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model. J. Vis. Exp. (111), e53573, doi:10.3791/53573 (2016).

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