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Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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Médecine
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Journal JoVE Médecine
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

7,831 Views

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06:21 min

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May 27, 2016

DOI:

10.3791/53573-v

DOI:
10.3791/53573-v

•

06:21 min
May 27, 2016

•

3 Views
, , , , , ,
1Department of Radiation Oncology,University of Toronto, 2Department of Physics,Ryerson University, 3Department of Medical Biophysics,University of Toronto, 4Ontario Cancer Institute / Campbell Family Institute for Cancer Research

Summary

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We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.

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Cite this Article

Chin, L., Korpela, E., Kim, A., Yohan, D., Niu, C., Wilson, B. C., Liu, S. K. Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model. J. Vis. Exp. (111), e53573, doi:10.3791/53573 (2016).

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