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Developmental Biology

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JoVE Journal Developmental Biology
Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
 

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

Article DOI: 10.3791/53062-v • 15:40 min • November 11th, 2015
November 11th, 2015 •
1, 1, 1
1Department of Cell and Developmental Biology, University of Colorado Denver

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Stress resistance is one of the hallmarks for longevity and is known to be genetically governed. Here, we developed an unbiased high-throughput method to screen for mutations that confer stress resistance in ES cells with which to develop mouse models for longevity studies.

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Keywords: Genetic Screen Forward Genetics Embryonic Stem Cells High-throughput Stress Resistance Paraquat Oxidative Stress Mouse Models Gene Function
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