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Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

17,474 Views

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09:24 min

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April 15, 2014

DOI:

10.3791/51154-v

DOI:
10.3791/51154-v

•

09:24 min
April 15, 2014

•

5 Views
, , , ,
1Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair,University of Cambridge, UK, 2NIHR Biomedical Research Center,University of Cambridge, UK

Summary

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The transplantation of neural stem/progenitor cells (NPCs) holds great promises in regenerative neurology. The systemic delivery of NPCs has turned into effective, low invasive, and therapeutically very efficacious protocol to deliver stem cells in the brain and spinal cord of rodents and nonhuman primates affected by experimental chronic inflammatory damage of the central nervous system.

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Neural Stem/progenitor CellsNPC TransplantationSystemic DeliveryIntravenous InjectionIntracerebroventricular InjectionExperimental Autoimmune EncephalomyelitisEAEChronic CNS Inflammatory DemyelinationBrain RepairRegenerative Neurology

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Cite this Article

Donegà, M., Giusto, E., Cossetti, C., Schaeffer, J., Pluchino, S. Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE. J. Vis. Exp. (86), e51154, doi:10.3791/51154 (2014).

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