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في النمذجة فيفو من المهووسين الجينوم البشري باستخدام دانيو rerio
JoVE Journal
Biologia
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JoVE Journal Biologia
In Vivo Modeling of the Morbid Human Genome using Danio rerio
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في النمذجة فيفو من المهووسين الجينوم البشري باستخدام دانيو rerio

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12:31 min

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August 24, 2013

DOI:

10.3791/50338-v

DOI:
10.3791/50338-v

•

12:31 min
August 24, 2013

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, , , , ,
1Center for Human Disease Modeling, Department of Cell Biology,Duke University Medical Center, 2Department of Evolutionary Anthropology,Duke University, 3Department of Pediatrics,Duke University Medical Center

Tags

ZebrafishIn Vivo ModelingHuman GenomeNonsynonymous ChangesComplementationMorpholinoMRNADevelopmental DefectsPediatric DiseaseAdult-onset DisordersOrthologousDominant NegativeGain Of FunctionLoss Of FunctionPhenotypingMorphogenetic SignalingCraniofacialCardiacVascularRenalSkeletal Muscle

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Niederriter, A. R., Davis, E. E., Golzio, C., Oh, E. C., Tsai, I., Katsanis, N. In Vivo Modeling of the Morbid Human Genome using Danio rerio. J. Vis. Exp. (78), e50338, doi:10.3791/50338 (2013).

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