Waiting
Elaborazione accesso...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Immunology and Infection / Dissecting Host-virus Interaction in Lytic…
JoVE Journal
Immunology and Infection

È necessario avere un abbonamento a JoVE per visualizzare questo Contenuto. Accedi o inizia la tua prova gratuita.

JoVE Journal Immunology and Infection
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
 

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Article DOI: 10.3791/3140-v • 11:29 min • October 7th, 2011
October 7th, 2011 •
1, 2
1Center for Autophagy Research, Department of Internal Medicine, UT Southwestern Medical Center, 2Department of Microbiology, UT Southwestern Medical Center

Capitoli

Riepilogo
Automatic Translation

We describe a protocol to identify key roles of host signaling molecules in lytic replication of a model herpesvirus, gamma herpesvirus 68 (γHV68). Utilizing genetically modified mouse strains and embryonic fibroblasts for γHV68 lytic replication, the protocol permits both phenotypic characterization and molecular interrogation of virus-host interactions in viral lytic replication.

Tags

Host-virus Interaction Lytic Replication Model Herpesvirus Viral Infection Innate Immune Signaling Pathways Antiviral Cytokine Production Viral Evasion Signaling Pathways Manipulation Therapeutic Strategies Murine γHV68 Kaposi's Sarcoma-associated Herpesvirus Epsten-Barr Virus Small Animal Model Phenotypic Characterization Molecular Dissection Host Signaling Components Genetically Modified Mouse Strains Acute Infection Mouse Embryonic Fibroblasts (MEFs) Virological Assays Molecular Biology Assays
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter