An experimental mouse model of bone metastasis was established following intracardiac delivery of luciferase expressing mammary tumor cells. Tumor development and resulted osteolytic lesion were monitored longitudinally with bioluminescence and micro CT imaging.
Lim, E., Modi, K., Christensen, A., Meganck, J., Oldfield, S., Zhang, N. Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging. J. Vis. Exp. (50), e2775, doi:10.3791/2775 (2011).