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May 18, 2010
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我们建立了脑室周围白质软化（PVL），早产儿脑室周围脑白质病变为特征的主导性脑损伤的小鼠模型。 / /没有全身性感染的缺氧缺血PVL的主要原因。单侧颈动脉结扎和缺氧暴露/无脂多糖注射创建在P6小鼠PVL的样病变。
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Mouse ModelsPeriventricular LeukomalaciaPVLBrain InjuryPremature InfantsCerebral PalsyWhite Matter DamageOligodendroglial InjuryHypoxia/ischemiaSystemic Infection/inflammationP6 MiceNeonatal Brain InjuryCarotid LigationEndotoxin Lipopolysaccharide (LPS)Myelin Basic Protein (MBP)O1Electron Microscopic ExaminationHippocampusThalamusDisease PathogenesisTransgenic Mouse StrainsDrug TrialsTherapeutic AgentsStem Cell TransplantationImmunodeficiency Mouse Strains
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Shen, Y., Plane, J. M., Deng, W. Mouse Models of Periventricular Leukomalacia. J. Vis. Exp. (39), e1951, doi:10.3791/1951 (2010).
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