JOVE JOURNAL

Ricerca sul cancro

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Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Jordi M. Lanis*¹, Matthew S. Lewis*¹, Hannah Strassburger¹, Kristina Larsen¹, Stacey M. Bagby², Adrian T. A. Dominguez², Juan A. Marín-Jiménez³, Roberta Pelanda¹, Todd M. Pitts², Julie Lang¹

¹Department of Immunology and Microbiology, School of Medicine,University of Colorado Denver Anschutz Medical Campus, ²Division of Oncology, School of Medicine,University of Colorado Denver Anschutz Medical Campus, ³Department of Medical Oncology,Catalan Institute of Oncology (ICO-L'Hospitalet)

Journal (Cancer Research)

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Neta Moskovits^1,2, Ella Itzhaki^1,2, Nataly Tarasenko^1,2, Eva Chausky^1,2, Avital Bareket-Samish³, Aleksandr Kaufman^1,2, Raisa Meerson^1,2, Salomon M. Stemmer^1,2,4

¹Felsenstein Medical Research Center, ²Davidoff Center, Rabin Medical Center, ³BioInsight Ltd., ⁴Sackler Faculty of Medicine,Tel Aviv University

Journal (Cancer Research)

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Jonathan Weitz¹, Kevin Christian Montecillo Gulay¹, Tatiana Hurtado de Mendoza¹, Herve Tiriac¹, Joel Baumgartner¹, Kaitlyn Kelly¹, Jula Veerapong¹, Andrew M. Lowy¹

¹Department of Surgery,University of California

Journal (Cancer Research)

X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

Elizabeth Kenyon^1,2, Erin Zaluzec^1,3, Katherine Powell^1,2, Maximilian Volk^1,4, Shatadru Chakravarty^2,5, Jeremy Hix^2,6, Matti Kiupel⁷, Erik M. Shapiro², Lorenzo F. Sempere^1,2

¹Precision Health Program,Michigan State University, ²Department of Radiology,Michigan State University, ³Department of Pharmacology & Toxicology,Michigan State University, ⁴College of Osteopathic Medicine,Michigan State University, ⁵TechInsights Inc., ⁶IQ Advanced Molecular Imaging Facility,Michigan State University, ⁷Veterinary Diagnostic Laboratory, College of Veterinary Medicine,Michigan State University

Journal (Cancer Research)

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Dimitri Gaber¹, Michal Aharoni-Simon¹, Ortal Zaks¹, Keren Ben-Yaakov¹, Ziv Rotfogel^1,2, Hana Leiba^1,2, Avital Eisenberg-Lerner*¹, Arie L. Marcovich*^1,2

¹Ophthalmology Research Laboratory,Kaplan Medical Center, ²Department of Ophthalmology, Kaplan Medical Center, Faculty of Medicine,The Hebrew University of Jerusalem

Journal (Cancer Research)

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Qi Wang¹, Chun-Hao Chen¹, Hongbo Xu², Sylvie Deborde^1,3, Richard J. Wong^1,3

¹Department of Surgery,Memorial Sloan Kettering Cancer Center, ²Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital,Capital Medical University, ³David M. Rubenstein Center for Pancreatic Cancer Research,Memorial Sloan Kettering Cancer Center

Journal (Cancer Research)

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Josephine Geertsen Keller^1,2, Karol Mizielinski³, Kamilla Vandsø Petersen^1,2, Magnus Stougaard^2,3,4, Birgitta R. Knudsen^1,3, Cinzia Tesauro³

¹Department of Molecular Biology and Genetics,Aarhus University, ²Department of Clinical Medicine,Aarhus University, ³VPCIR Biosciences ApS, ⁴Department of Pathology,Aarhus University Hospital

Journal (Cancer Research)

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Giuseppina Bonizzi*¹, Maria Capra*¹, Cristina Cassi¹, Giulio Taliento¹, Oriana Pala², Elham Sajjadi^2,3, Konstantinos Venetis^2,3, Mariia Ivanova², Massimo Monturano⁴, Giuseppe Renne², Lorenzo Zattoni^1,3, Elena Guerini-Rocco^2,3, Giuseppe Viale^2,3, Roberto Orecchia⁵, Nicola Fusco^1,2,3

¹Biobank for Translational and Digital Medicine Unit,IEO, European Institute of Oncology IRCCS, ²Division of Pathology,IEO, European Institute of Oncology IRCCS, ³Department of Oncology and Hemato-Oncology,University of Milan, ⁴Patient Safety & Risk Management Service,IEO, European Institute of Oncology IRCCS, ⁵Scientific Directorate,IEO, European Institute of Oncology IRCCS

Journal (Cancer Research)

Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging

Serena L. Cornelius^1,2, Megan M. Colonnetta^2,3,4,5, Katherine E. Lake^1,2, Clayton A. Smith^1,2, Yu-An Zhang^1,2, Evanthia T. Roussos-Torres⁶, Sangeetha M. Reddy^1,2, Elizabeth H. Chen^2,3,4,5, Isaac S. Chan^1,2,3,4

¹Department of Internal Medicine, Division of Hematology and Oncology,University of Texas Southwestern Medical Center, ²Harold C. Simmons Comprehensive Cancer Center,University of Texas Southwestern Medical Center, ³Department of Molecular Biology,University of Texas Southwestern Medical Center, ⁴Hamon Center for Regenerative Science and Medicine,University of Texas Southwestern Medical Center, ⁵Department of Cell Biology,University of Texas Southwestern Medical Center, ⁶Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine,University of Southern California

Journal (Cancer Research)

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Junli Chang*^1,2, Xingyuan Sun*^1,2, Xiaoping Ma^1,2, Peng Zhao^1,2, Binhao Shi^1,2, Yongjun Wang^1,2, Xianghui Han^1,3, Yanping Yang^1,2

¹Longhua Hospital,Shanghai University of Traditional Chinese Medicine, ²Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education, ³Institute of Chinese Traditional Surgery, Longhua Hospital,Shanghai University of Traditional Chinese Medicine

Journal (Cancer Research)

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Leena Arora*¹, Moyna Kalia*¹, Soumyajit Roy¹, Durba Pal¹

¹Department of Biomedical Engineering,Indian Institute of Technology Ropar

Journal (Cancer Research)

High-Resolution Ultrasonography for the Analysis of Orthotopic ATC Tumors in a Genetically Engineered Mouse Model

Yushuang He¹, Yan Luo¹, Zhihui Li², Han Luo², Huayun Yan³, Yingfang Ma³, Xinyue Zhou²

¹Department of Ultrasound, West China Hospital,Sichuan University, ²Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital,Sichuan University, ³State Key Laboratory of Biotherapy and Cancer Center, West China Hospital,Sichuan University and Collaborative Innovation Center

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