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Capturing Chromosome Conformation Across Length Scales
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January 20, 2023
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Hi-C 3.0 is an improved Hi-C protocol that combines formaldehyde and disuccinimidyl glutarate crosslinkers with a cocktail of DpnII and DdeI restriction enzymes to increase the signal-to-noise ratio and the resolution of chromatin interaction detection.
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Yang, L., Akgol Oksuz, B., Dekker, J., Gibcus, J. H. Capturing Chromosome Conformation Across Length Scales. J. Vis. Exp. (191), e64001, doi:10.3791/64001 (2023).
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