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A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1
 

A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

Article DOI: 10.3791/63482-v • 12:36 min • July 22nd, 2022
July 22nd, 2022 •
1, 1, 1, 1
1Trefoil Therapeutics, Inc.

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Descemet's Stripping Only is an experimental procedure wherein patients with central corneal guttae resulting from Fuchs Endothelial Corneal Dystrophy have Descemet's membrane stripped for peripheral cells to regenerate the endothelial layer. We present novel methodology simulating DSO in dystrophic human corneas ex vivo with accelerated healing stimulated by eFGF1 (NM141).

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Keywords: Corneal Organ Culture Descemet's Stripping Only (DSO) Fuch's Endothelial Corneal Dystrophy (FECD) Engineered Fibroblast Growth Factor 1 Endothelial Keratoplasty Corneal Endothelial Cells Descemet's Membrane Corneal Guttae Wound Healing Corneal Transplantation
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