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얼룩말 물고기 애벌레의 척추 모터 뉴런에서 TDP-43의 광유전학 적 단계 전환

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Neurosciences

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Journal JoVE Neurosciences

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

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얼룩말 물고기 애벌레의 척추 모터 뉴런에서 TDP-43의 광유전학 적 단계 전환

5,742 Views

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07:14 min

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February 25, 2022

DOI:

10.3791/62932-v

DOI:

10.3791/62932-v

•

07:14 min

February 25, 2022

•

3 Views

Kazuhide Asakawa¹, Hiroshi Handa¹, Koichi Kawakami^2,3

¹Department of Chemical Biology,Tokyo Medical University, ²Division of Molecular and Developmental Biology,National Institute of Genetics, ³Department of Genetics,Graduate University for Advanced Studies (SOKENDAI)

Summary

우리는 제브라피시를 모델로 사용하여 척추 운동 뉴런의 빛에 의한 TAR DNA 결합 단백질(43)의 위상 전이를 유도하는 프로토콜을 설명합니다.

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