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JoVE Journal Behavior
Animal Models of Depression - Chronic Despair Model (CDM)
 

Animal Models of Depression - Chronic Despair Model (CDM)

Article DOI: 10.3791/62579-v • 05:47 min • September 23rd, 2021
September 23rd, 2021 •
1,2, 3,4, 1,5
1Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 2Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, 3Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 4Department of Stereotactic and Functional Neurosurgery, Medical Center - University Freiburg, Faculty of Medicine, University of Freiburg, 5Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg

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The chronic despair mouse model (CDM) of depression consists of repetitive forced swim sessions and another delayed swim phase as a read-out. It represents a suitable model for induction of a chronic depressive-like state stable for at least 4 weeks, amendable to evaluate subchronic and acute treatment interventions.

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Keywords: Animal Models Depression Chronic Despair Model CDM Chronic Stress Forced Swim Test Immobility Time Antidepressant Evaluation
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