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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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March 19, 2021
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A protocol for the culture and manipulation of mouse embryonic tissue on a microfluidic chip is provided. By applying pulses of pathway modulators, this system can be used to externally control signaling oscillations for the functional investigation of mouse somitogenesis.
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van Oostrom, M. J., Meijer, W. H. M., Sonnen, K. F. A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis. J. Vis. Exp. (169), e62318, doi:10.3791/62318 (2021).
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