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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
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Médecine
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Journal JoVE Médecine
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

4,213 Views

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09:56 min

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February 14, 2021

DOI:

10.3791/62101-v

DOI:
10.3791/62101-v

•

09:56 min
February 14, 2021

•

27 Views
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1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy,Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School,Institute for Neurophysiology

Summary

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The baroreflex is a heart-rate regulation mechanism by the autonomic nervous system in response to blood-pressure changes. We describe a surgical technique to implant telemetry transmitters for continuous and simultaneous measurement of electrocardiogram and blood pressure in mice. This can determine spontaneous baroreflex sensitivity, an important prognostic marker for cardiovascular disease.

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Rötzer, R. D., Brox, V. F., Hennis, K., Thalhammer, S. B., Biel, M., Wahl-Schott, C., Fenske, S. Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice. J. Vis. Exp. (168), e62101, doi:10.3791/62101 (2021).

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