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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
JoVE 杂志
医学
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JoVE 杂志 医学
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

DOI:
10.3791/62101-v

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09:56 min

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February 14, 2021

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, , , , , ,
1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy,Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School,Institute for Neurophysiology

Chapters

  • 00:05Introduction
  • 01:34Dissection of the Left Common Carotid
  • 04:09Cannulation of the Left Common Carotid Artery
  • 05:11Placement of the Telemetry Device Body and ECG Leads
  • 07:29Results: Analysis of BRS Using the Sequence Method on Simultaneous Telemetric ECG and BP Recordings
  • 08:58Conclusion

Summary

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The baroreflex is a heart-rate regulation mechanism by the autonomic nervous system in response to blood-pressure changes. We describe a surgical technique to implant telemetry transmitters for continuous and simultaneous measurement of electrocardiogram and blood pressure in mice. This can determine spontaneous baroreflex sensitivity, an important prognostic marker for cardiovascular disease.

Tags

TelemetryECGBlood PressureBaroreflex SensitivityConscious MiceCardiovascular DiseaseMicrosurgeryCarotid ArteryAnesthesiaDepilatory CreamSkin IncisionBlunt DissectionParotid GlandSubmandibular GlandTrachea

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