00:45Native MS Acquisition and Analysis for Investigating Protein Complexes and Protein-Ligand Complexes
03:51Acquiring and Analyzing IM-MS
04:34In-Solution Disruption of Protein Complexes for Native MS and IM-MS Led Structure Determination and Investigating Protein Complex Stability using Collision Induced Unfolding
05:45Results: Integrative Structural Mass Spectrometry of Protein Architectures and Protein-Ligand Complexes
Mass spectrometry (MS) has emerged as an important tool for the investigation of structure and dynamics of macromolecular assemblies. Here, we integrate MS-based approaches to interrogate protein complex formation and ligand binding.