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Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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October 15, 2018
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Mass spectrometry (MS) has emerged as an important tool for the investigation of structure and dynamics of macromolecular assemblies. Here, we integrate MS-based approaches to interrogate protein complex formation and ligand binding.
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Protein ArchitectureProtein-ligand ComplexStructural Mass SpectrometryNative Mass SpectrometryBiomolecular AssembliesHeterogeneous Protein SamplesOligomeric StateNanoelectrosprayAmmonium AcetateIon Mobility SeparationCapillary HolderNano-flow Gas PressureCapillary VoltageSampling ConeSource OffsetSource TemperatureCone Gas FlowTrap Collision EnergyTrap Voltage
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Ahdash, Z., Lau, A. M., Martens, C., Politis, A. Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry. J. Vis. Exp. (140), e57966, doi:10.3791/57966 (2018).
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