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JoVE Journal Neuroscience
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
 

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Article DOI: 10.3791/57349-v • 07:33 min • June 29th, 2018
June 29th, 2018 •
1,2, 2,3, 1,2
1Systems Neurophysiology Research Group, Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 2Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/ NeuroCure Cluster of Excellence, 3Neuronal Circuits and Behavior Research Group, Max Planck Institute for Metabolism Research

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résumé
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We describe the use of optogenetics and electrophysiological recordings for selective manipulations of hippocampal theta oscillations (5-10 Hz) in behaving mice. The efficacy of the rhythm entrainment is monitored using local field potential. A combination of opto- and pharmacogenetic inhibition addresses the efferent readout of hippocampal synchronization.

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Hippocampal Theta Oscillations Neurophysiology Causal Role Special Navigation Associated Behaviors Real-time Control Frequency Regularity Behaving Mice Dr. Franziska Bender Grad Student Stereotaxic Frame Injection Needle Virus Paraffin Film Nanoliters Per Minute Craniotomy Optic Fiber
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