Aneuploidy leads to genome instability, which eventually produces cell cycle-arrested cells with complex karyotypes. This paper provides a simple and convenient method to isolate aneuploid cells with complex karyotypes that cease to divide.
Wang, R. W., MacDuffie, E., Santaguida, S. Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes. J. Vis. Exp. (134), e57215, doi:10.3791/57215 (2018).