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Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
Journal JoVE
Biologie du développement
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Journal JoVE Biologie du développement
Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
DOI:

08:43 min

April 03, 2018

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Chapitres

  • 00:04Titre
  • 00:46Preparation of 3D Human Tissue Equivalents of Gingiva
  • 04:17Preparation of Wounded and Inflammatory GTE
  • 05:46Results: Characterize the 3D Inflammatory Human Tissue Equivalents of Gingiva (iGTE)
  • 07:30Conclusion

Summary

Traduction automatique

The goal of the protocol is to build an inflammatory human gingiva model in vitro. This tissue model co-cultivates three types of human cells, HaCaT keratinocytes, gingival fibroblasts, and THP-1 macrophages, under three-dimensional conditions. This model can be applied to investigating periodontal diseases, such as gingivitis and periodontitis.

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