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Immunologie et infection
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Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis
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Immunologie et infection
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Journal JoVE Immunologie et infection
Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis

Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis

7,050 Views

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06:09 min

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September 30, 2017

DOI:

10.3791/56123-v

DOI:
10.3791/56123-v

•

06:09 min
September 30, 2017

•

3 Views
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1South Texas Center for Emerging Infectious Diseases,University of Texas San Antonio, 2Midwestern University

Summary

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This protocol describes intratracheal inoculations of Fischer 344 rats with Francisella tularensis. This procedure mimics pulmonary exposure of humans to this potential biothreat agent and can be used to test vaccine and therapeutic efficacy against pulmonary tularemia.

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Intratracheal InoculationFischer 344 RatsFrancisella TularensisPulmonary TularemiaVaccine EfficacyBiothreat AgentPulmonary Infectious Disease ModelPlagueCatheterTracheaEsophagusAnesthesiaLaryngoscope

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Cite this Article

Nguyen, J. Q., Zogaj, X., Adelani, A. A., Chu, P., Yu, J., Arulanandam, B. P., Klose, K. E. Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis. J. Vis. Exp. (127), e56123, doi:10.3791/56123 (2017).

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