Journal
/
Biologie du développement
/
源自iPSC的人脑组织体的一代新型早期神经发育障碍
Journal JoVE
Biologie du développement
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Biologie du développement
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
Please note that all translations are automatically generated. Click here for the English version.

源自iPSC的人脑组织体的一代新型早期神经发育障碍

19,249 Views

•

07:40 min

•

April 14, 2017

DOI:

10.3791/55372-v

DOI:
10.3791/55372-v

•

07:40 min
April 14, 2017

•

16 Views
,
1Center for Molecular Medicine Cologne,University of Cologne, 2Institute for Biochemistry I,Medical School of University of Cologne

Summary

Automatically generated

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

Explore More Videos

IPSCBrain OrganoidsNeurodevelopmental DisordersNeurogenesisPrimary MicrocephalyNeurospheresEHS MatrixSpinner FlaskBrain Organoid MediumOrganoid Culture

Read Article

Cite this Article

Gabriel, E., Gopalakrishnan, J. Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders. J. Vis. Exp. (122), e55372, doi:10.3791/55372 (2017).

Download .ris file

Copy

Share Video

.

Copy