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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
Journal JoVE
Génétique
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Journal JoVE Génétique
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

8,843 Views

10:06 min

April 26, 2017

DOI:

10:06 min
April 26, 2017

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Summary

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This report describes a bioengineering method to design and construct novel Artificial Splicing Factors (ASFs) that specifically modulate the splicing of target genes in mammalian cells. This method can be further expanded to engineer various artificial factors to manipulate other aspects of RNA metabolism.

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