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Intubation-mediated Intratracheal (IMIT) Instillation: A Noninvasive, Lung-specific Delivery System
Journal JoVE
Médecine
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Journal JoVE Médecine
Intubation-mediated Intratracheal (IMIT) Instillation: A Noninvasive, Lung-specific Delivery System

Intubation-mediated Intratracheal (IMIT) Instillation: A Noninvasive, Lung-specific Delivery System

DOI:
10.3791/52261-v

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08:00 min

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November 17, 2014

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, , ,
1Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases,University of Louisville Medical School, 2Department of Microbiology and Immunology,University of Louisville Medical School

Chapitres

  • 00:05Titre
  • 02:09IMIT Instillation
  • 04:52Characterization of IMIT Delivery
  • 06:03Results: Representative IMIT Bacterial Instillation in the Mouse Lung
  • 06:48Conclusion

Summary

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Intubation-mediated intratracheal (IMIT) instillation of reagents is an excellent, noninvasive method for studying respiratory disease, as well as a method for instilling therapeutic reagents directly into the lung. It is a rapid and highly reproducible method which is suitable for preclinical testing.

Tags

Intubation-mediated Intratracheal (IMIT) InstillationLung-specific Delivery SystemMurine Respiratory SystemLower Respiratory Tract (LRT) DiseaseIntranasal InstillationNoninvasive TechniqueIntratracheal InfectionLung DeliveryGood Laboratory Practice Standards (GLPS)

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