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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
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May 12, 2013
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We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to rats.
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DeVos, S. L., Miller, T. M. Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System. J. Vis. Exp. (75), e50326, doi:10.3791/50326 (2013).
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