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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
Chapters
- 00:05Title
- 01:54Pre-Surgical Procedure
- 03:49Implantation of Alzet Osmotic Pump
- 08:01Changing or Removing Alzet Osmotic Pump
- 09:51Administration of an Intracerebroventricular Bolus
- 12:12Results: Intraventricular Delivery of Antisense Oligonucleotides to the Rodent Central Nervous System
- 14:36Conclusion
We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to rats.
