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嗜碱粒细胞激活测试IgE介导的药物过敏机制的调查
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September 16, 2011
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嗜碱性粒细胞活化试验是一种IgE依赖的过敏检测的有力工具<em>在体外</em>。在这里，嗜碱性粒细胞活化试验的优化协议是用来研究药物过敏。一种高效的生产药物蛋白的共价结合物及其理化性质的方法是描述。
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Basophil Activation TestInvestigationIgE-Mediated MechanismsDrug HypersensitivityNon-steroidal Anti-inflammatory DrugsPropyphenazoneDiclofenacType I-like Allergic ReactionsClinical PracticePatient HistorySkin TestingOral Provocation TestingIgE-mediated PathomechanismIn Vitro MethodHuman BasophilsDrug-allergic PatientsIgE Receptor CrosslinkingAllergic Effector MoleculesCD63 Surface ExpressionFlow CytometryLow Molecular Weight DrugsConjugatesHuman Serum Albumin (HSA)Carboxyl Group
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Steiner, M., Harrer, A., Lang, R., Schneider, M., Ferreira, F., Hawranek, T., Himly, M. Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity. J. Vis. Exp. (55), e3263, doi:10.3791/3263 (2011).
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