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Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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August 24, 2011
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The autologous blood injection model of intracerebral hemorrhage in mice described in this protocol uses the double injection technique to minimize risk of blood reflux up the needle track, no anticoagulants in the pumping system, and eliminates all dead space and expandable tubing in the system.
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Autologous Blood InjectionSpontaneous Intracerebral HemorrhageMice ModelPathophysiology Of InjuryIntracerebral HemorrhageReproducible Animal ModelEffective TherapyStereotaxic InjectionArterial BloodBasal GangliaSpontaneous Hypertensive HemorrhageNeurobehavioral DeficitsPotential Therapeutic AgentsDouble Injection TechniqueBlood RefluxAnticoagulantsDead SpaceExpandable Tubing
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Sansing, L. H., Kasner, S. E., McCullough, L., Agarwal, P., Welsh, F. A., Kariko, K. Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice. J. Vis. Exp. (54), e2618, doi:10.3791/2618 (2011).
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