Nicholas M. Kanaan Department of Translational Neuroscience, College of Human Medicine Michigan State University Biography Publications Institution JoVE Articles Nicholas M. Kanaan has not added a biography. If you are Nicholas M. Kanaan and would like to personalize this page please email our Author Liaison for assistance. Publications Tau Here, Tau There, Tau Almost Everywhere: Clarifying the Distribution of Tau in the Adult CNS Cytoskeleton (Hoboken, N.J.). Dec, 2023 | Pubmed ID: 38102924 Behavioral and Neuropathological Characterization over the Adult Lifespan of the Human Tau Knock-in Mouse Frontiers in Aging Neuroscience. 2023 | Pubmed ID: 37842124 CRISPR Screens in IPSC-derived Neurons Reveal Principles of Tau Proteostasis BioRxiv : the Preprint Server for Biology. Jun, 2023 | Pubmed ID: 37398204 Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons Molecular Neurobiology. Jun, 2023 | Pubmed ID: 36859689 Central Role for P62/SQSTM1 in the Elimination of Toxic Tau Species in a Mouse Model of Tauopathy Aging Cell. Jul, 2022 | Pubmed ID: 35662390 Mitochondrial Oxidative Stress Contributes to the Pathological Aggregation and Accumulation of Tau Oligomers in Alzheimer's Disease Human Molecular Genetics. Aug, 2022 | Pubmed ID: 35165721 Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein International Journal of Molecular Sciences. Nov, 2021 | Pubmed ID: 34769495 Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport Through a Protein Phosphatase 1γ-Dependent Mechanism The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2021 | Pubmed ID: 34607969 EFhd2 Brain Interactome Reveals Its Association with Different Cellular and Molecular Processes Journal of Neurochemistry. 12, 2021 | Pubmed ID: 34543436 Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 33986642 Tau: A Signaling Hub Protein Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 33815057 TIA1 Potentiates Tau Phase Separation and Promotes Generation of Toxic Oligomeric Tau Proceedings of the National Academy of Sciences of the United States of America. Mar, 2021 | Pubmed ID: 33619090 Tau is Not Necessary for Amyloid-β-induced Synaptic and Memory Impairments The Journal of Clinical Investigation. Sep, 2020 | Pubmed ID: 32544084 Liquid-liquid Phase Separation Induces Pathogenic Tau Conformations in Vitro Nature Communications. Jun, 2020 | Pubmed ID: 32499559 A Human Induced Pluripotent Stem Cell-derived Cortical Neuron Human-on-a Chip System to Study Aβ and Tau-induced Pathophysiological Effects on Long-term Potentiation Alzheimer's & Dementia (New York, N. Y.). 2020 | Pubmed ID: 32490141 Rho-kinase ROCK Inhibitors Reduce Oligomeric Tau Protein Neurobiology of Aging. May, 2020 | Pubmed ID: 31982202 Tau and Axonal Transport Misregulation in Tauopathies Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 32096030 Activity of the Poly(A) Binding Protein MSUT2 Determines Susceptibility to Pathological Tau in the Mammalian Brain Science Translational Medicine. Dec, 2019 | Pubmed ID: 31852801 EFhd2 Affects Tau Liquid-Liquid Phase Separation Frontiers in Neuroscience. 2019 | Pubmed ID: 31456657 Time Course and Magnitude of Alpha-synuclein Inclusion Formation and Nigrostriatal Degeneration in the Rat Model of Synucleinopathy Triggered by Intrastriatal α-synuclein Preformed Fibrils Neurobiology of Disease. 10, 2019 | Pubmed ID: 31276792 Pathogenic Tau Modifications Occur in Axons Before the Somatodendritic Compartment in Mossy Fiber and Schaffer Collateral Pathways Acta Neuropathologica Communications. Feb, 2019 | Pubmed ID: 30819250 Pretangle Pathology Within Cholinergic Nucleus Basalis Neurons Coincides with Neurotrophic and Neurotransmitter Receptor Gene Dysregulation During the Progression of Alzheimer's Disease Neurobiology of Disease. Sep, 2018 | Pubmed ID: 29859871 Correction To: Lewy Body-like Alpha-synuclein Inclusions Trigger Reactive Microgliosis Prior to Nigral Degeneration Journal of Neuroinflammation. May, 2018 | Pubmed ID: 29843738 Lewy Body-like Alpha-synuclein Inclusions Trigger Reactive Microgliosis Prior to Nigral Degeneration Journal of Neuroinflammation. May, 2018 | Pubmed ID: 29716614 Tau Kinetics in Neurons and the Human Central Nervous System Neuron. Mar, 2018 | Pubmed ID: 29566794 Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization International Journal of Molecular Sciences. Mar, 2018 | Pubmed ID: 29562600 Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2018 | Pubmed ID: 29516269 Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease Journal of Neuropathology and Experimental Neurology. Mar, 2018 | Pubmed ID: 29378005 Reducing the RNA Binding Protein TIA1 Protects Against Tau-mediated Neurodegeneration in Vivo Nature Neuroscience. Jan, 2018 | Pubmed ID: 29273772 Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms Frontiers in Neuroscience. 2017 | Pubmed ID: 29089864 Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS Molecular Therapy. Nucleic Acids. Sep, 2017 | Pubmed ID: 28918020 Production of Recombinant Tau Oligomers in Vitro Methods in Cell Biology. 2017 | Pubmed ID: 28882311 Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats ENeuro. 2017 | Pubmed ID: 28785724 Aging and Parkinson's Disease: Different Sides of the Same Coin? Movement Disorders : Official Journal of the Movement Disorder Society. Jul, 2017 | Pubmed ID: 28520211 Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies The American Journal of Pathology. Jun, 2017 | Pubmed ID: 28413156 Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 27909397 Progression of Tau Pathology Within Cholinergic Nucleus Basalis Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study Brain Injury. 2016 | Pubmed ID: 27834536 Soluble Pre-fibrillar Tau and β-amyloid Species Emerge in Early Human Alzheimer's Disease and Track Disease Progression and Cognitive Decline Acta Neuropathologica. Dec, 2016 | Pubmed ID: 27770234 Calcium Dysregulation Contributes to Neurodegeneration in FTLD Patient IPSC-derived Neurons Scientific Reports. 10, 2016 | Pubmed ID: 27721502 Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition Neurobiology of Aging. 11, 2016 | Pubmed ID: 27574109 Pioglitazone Prevents Tau Oligomerization Biochemical and Biophysical Research Communications. Sep, 2016 | Pubmed ID: 27543203 Pseudophosphorylation of Tau at S422 Enhances SDS-stable Dimer Formation and Impairs Both Anterograde and Retrograde Fast Axonal Transport Experimental Neurology. Sep, 2016 | Pubmed ID: 27373205 Pathological Conformations Involving the Amino Terminus of Tau Occur Early in Alzheimer's Disease and Are Differentially Detected by Monoclonal Antibodies Neurobiology of Disease. Oct, 2016 | Pubmed ID: 27260838 Protein Homeostasis Gene Dysregulation in Pretangle-bearing Nucleus Basalis Neurons During the Progression of Alzheimer's Disease Neurobiology of Aging. Jun, 2016 | Pubmed ID: 27143424 Quantitative and Semi-quantitative Measurements of Axonal Degeneration in Tissue and Primary Neuron Cultures Journal of Neuroscience Methods. Jun, 2016 | Pubmed ID: 27031947 Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy Journal of Neuropathology and Experimental Neurology. Jan, 2016 | Pubmed ID: 26671985 Gene Therapy Models of Alzheimer's Disease and Other Dementias Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26611599 Intrastriatal Injection of Pre-formed Mouse α-synuclein Fibrils into Rats Triggers α-synuclein Pathology and Bilateral Nigrostriatal Degeneration Neurobiology of Disease. Oct, 2015 | Pubmed ID: 26093169 The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-hydroxydopamine Reveals Significant Upregulation of Regeneration-associated Genes PloS One. 2015 | Pubmed ID: 25992874 A Method for Combining RNAscope in Situ Hybridization with Immunohistochemistry in Thick Free-floating Brain Sections and Primary Neuronal Cultures PloS One. 2015 | Pubmed ID: 25794171 Recombinant Adenoassociated Virus 2/5-mediated Gene Transfer is Reduced in the Aged Rat Midbrain Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25457558 Axonal Degeneration in Alzheimer's Disease: when Signaling Abnormalities Meet the Axonal Transport System Experimental Neurology. Aug, 2013 | Pubmed ID: 22721767 Loss of Functional Alpha-synuclein: a Toxic Event in Parkinson's Disease? Journal of Parkinson's Disease. 2012 | Pubmed ID: 23938255 Phosphorylation in the Amino Terminus of Tau Prevents Inhibition of Anterograde Axonal Transport Neurobiology of Aging. Apr, 2012 | Pubmed ID: 21794954 Heat Shock Protein 70 Prevents Both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport Biochemistry. Nov, 2011 | Pubmed ID: 22039833 Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease The American Journal of Pathology. Nov, 2011 | Pubmed ID: 21945902 Pathogenic Forms of Tau Inhibit Kinesin-dependent Axonal Transport Through a Mechanism Involving Activation of Axonal Phosphotransferases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2011 | Pubmed ID: 21734277 Ageing As a Primary Risk Factor for Parkinson's Disease: Evidence from Studies of Non-human Primates Nature Reviews. Neuroscience. Jun, 2011 | Pubmed ID: 21587290 Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21550980 Tyrosine Nitration Within the Proline-rich Region of Tau in Alzheimer's Disease The American Journal of Pathology. May, 2011 | Pubmed ID: 21514440 Peroxynitrite-induced Nitrative and Oxidative Modifications Alter Tau Filament Formation Biochemistry. Feb, 2011 | Pubmed ID: 21210655 Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases Rebecca L. Mueller1,2, Nicholas M. Kanaan1,2,3, Benjamin Combs1 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Neuroscience Program, Michigan State University, 3Hauenstein Neuroscience Center, Mercy Health Saint Mary’s JoVE 66156 Neurosciences Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo Joseph R. Patterson1, Nicole K. Polinski2, Megan F. Duffy1,3, Christopher J. Kemp1, Kelvin C. Luk4, Laura A. Volpicelli-Daley5, Nicholas M. Kanaan1, Caryl E. Sortwell1,3,6 1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center JoVE 59758 Neurosciences
Author Spotlight: Understanding the Impact of Pathological Proteins on Axonal Transport in Neurodegenerative Diseases Rebecca L. Mueller1,2, Nicholas M. Kanaan1,2,3, Benjamin Combs1 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Neuroscience Program, Michigan State University, 3Hauenstein Neuroscience Center, Mercy Health Saint Mary’s JoVE 66156 Neurosciences
Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo Joseph R. Patterson1, Nicole K. Polinski2, Megan F. Duffy1,3, Christopher J. Kemp1, Kelvin C. Luk4, Laura A. Volpicelli-Daley5, Nicholas M. Kanaan1, Caryl E. Sortwell1,3,6 1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center JoVE 59758 Neurosciences