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Evaluering af motorisk svækkelse i C. elegans Modeller af Amyotrofisk Lateral Sklerose
JoVE Revista
Neurociencias
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JoVE Revista Neurociencias
Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluering af motorisk svækkelse i C. elegans Modeller af Amyotrofisk Lateral Sklerose

DOI:
10.3791/62699-v

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08:27 min

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September 02, 2021

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1Geriatrics Research Education and Clinical Center,Veterans Affairs Puget Sound Health Care System, 2Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington

Capítulos

  • 00:04Introduction
  • 00:45Radial Locomotion Assay
  • 02:10Computer-Analyzed Swimming Assay
  • 05:51Data Analysis
  • 06:19Results: Analysis of the Crawling Speeds in Radial Locomotion and Thrashing in the Swimming Assay
  • 07:48Conclusion

Summary

Traducción Automática

Traducción Automática

Denne protokol beskriver to følsomme assays til kræsning blandt mild, moderat, og svær motorisk svækkelse i C. elegans modeller af amyotrofisk lateral sklerose, med generelle nytte for C. elegans stammer, med ændret motilitet.

Tags

Keywords: C. ElegansAmyotrophic Lateral Sclerosis (ALS)Motor ImpairmentRadial Locomotion AssaySwimming AssayMotility PhenotypesMovement QuantificationComputer-based TrackingThrashing Movements

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