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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
 

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Article DOI: 10.3791/60186-v • 09:32 min • September 26th, 2019
September 26th, 2019 •
*1, *2, 1, 3, 4, 4, 2, 2
1Procter and Gamble, Beijing Innovative center, 2Procter and Gamble, Mason Business Center, 3Department of Dermatology, Beijing Children's Hospital, 4Chinese Academy of Inspection and Quarantine
* These authors contributed equally

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Here, we present a protocol for collection of confocal Raman spectra from human subjects in clinical studies combined with chemometric approaches for spectral outlier removal and the subsequent extraction of key features.

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Water Proteins Lipids In Vivo Confocal Raman Spectra Chemometric Approach Depth Resolution Skin-related Diseases Skincare Product Performance Clinical Raman Data Set Spectroscopic Artifacts Outliers Data Analysis Key Components Prior Knowledge C&T Lab Imaging Window
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